A short take on how computational approaches leverage multimodal single cell (RNA+ATAC) for inference of regulatory networks and a brief review of recent ground-breaking work by Dictys, SCENIC+ and MIRA at https://rdcu.be/disS3
In a study lead by Tiago Maié, we present a computational pipeline for the detection of accurate DNA methylation signatures for cell type identification and cell deconvolution. Check the manuscript here!
We are delighted to have our manuscript co-lead by Zhijian Li being published in Nature! Great collaboration with R. Kramann and Saez lab! Check our our pre-print on a novel computational framework for computing gene regulatory networks from single cell …
Paper on spatial map of the myocardial infarction published in Nature! Read more »
We are happy to have two fresh PhDs from the lab! We wish you all the luck to Li & Li on their future work on Broad Institute and Shandong University Hospital!
Our manuscript describing a fast and universal integration approach for multiome protocols was accepted as a paper at ISMB 2022 and will soon appears in Bioinformatics Journal. A pre-print is found here.
The paper “The area under the ROC curve as a measure of clustering quality” was published in a special issue in “Data Mining and Knowledge Discovery” and accepted for a talk at ECML/PKDD 2022. Congrats to Pablo!
In a recently published work, we were able to show that there is increased scarring of the kidneys in patients who died after intensive care treatment for COVID19. Our data with kidney organoids from human induced pluripotent stem cells showed …
Kidney Fibrosis after COVID Infection / Study published in Cell Stem Cell Read more »
The 2nd annual meeting of the Fibromap consortia will take place at the 12.1.2022 from 9:00 and 13:00. The meeting will be virtual via zoom. Please use the following link for registration: here. Time Speaker Title 9:00 Ivan G. Costa …
In a joint work, M.Sc. Zhijian Li and Prof. Ivan G. Costa, Institute for Computational Genomics, and Dr. Christoph Kuppe and Prof. Rafael Kramann, Institute for Experimental Internal Medicine and Systems Biology of the Uniklinik RWTH Aachen developed a machine …
