In a joint work, M.Sc. Zhijian Li and Prof. Ivan G. Costa, Institute for Computational Genomics, and Dr. Christoph Kuppe and Prof. Rafael Kramann, Institute for Experimental Internal Medicine and Systems Biology of the Uniklinik RWTH Aachen developed a machine …

De-noising of single cell ATAC-seq and identification of TFs driving fibrosis in Kidney with scOpen published in Nature Communications Read more »

In a joint effort, the Institute for Computational Genomics at the Uniklinik RWTH Aachen and collaborators from Ulm University (Germany) and the Cochin Institute (Paris, France) have characterized the role of the transcription factor ONECUT1 in diabetes, which was recently …

Work on genetic variants in ONECUT1 associated to diabetes accepted in Nature Medicine Read more »

Imputation and footprinting for single cell ATAC-seq. New manuscript & software release! scOpen deals with massive sparsity and dropout events of single cell ATAC-seq. Use of scOpen improves clustering, inference of regulators and chromatin conformation. scHINT dissect regulatory & temporal …

Imputation and footprinting for single cell ATAC-seq. New manuscript & software release! Read more »