The Federal Ministry of Education and Research (BMBF) is funding the research project „Spatial Mapping of Single Cells in Fibrotic Disease“, FibroMap for short, of the Uniklinik RWTH Aachen with 3.3 million euros. The Aachen scientists Prof. Dr. med. Dr.…

We are looking for an experienced bioinformatician for helping the creation a spatial map of fibrosis. The candidate will develop bioinformatic methods for tracking temporal changes of  single cells and integrative analysis of scRNA-seq, scATAC-seq and spatial information. This position…

Imputation and footprinting for single cell ATAC-seq. New manuscript & software release! scOpen deals with massive sparsity and dropout events of single cell ATAC-seq. Use of scOpen improves clustering, inference of regulators and chromatin conformation. scHINT dissect regulatory & temporal…

Joseph having a hard time in keeping his new hat in the head! 

Collaborative work with Krenkel and Tacke dissect changes in immune cells of mice subjected to high fat / high sugar diets.

Our paper on HINT-ATAC  is finally out in Genome Biology!

A paper describing TDF- a framework for detection of triple helix forming RNAs  – is finally out in NAR! Moreover with Grummt Lab, we have performed computational analysis of TripleRNA-seq and TriplexDNA-seq; two novel protocols for returning DNA/RNA molecules forming…

We perform research on computational methods for analysis of epigenomics and transcriptomics data. Over the past years, we have developed methods for prediction of cell specific binding sites from open chromatin data (Gusmao et al., Bioinformatics, 2015; Nature Methods, 2016),…

Together with Kurian lab, we have delineated bionformatics framework to uncover novel antisense lncRNAs during cardiomyocite differentiation. These were particularly positioned up-stream of transcription factors, and showed a high positive correlation with these anti-sense partners.In this paper, Frank and colleagues…

A few successful collaborative efforts were recently published in top biomedical journals. With Zirkel and colleagues we used HINT footprint analysis to characterize transcription factor binding underlying DNA looping via HMGB2. With Sonntag and colleagues, we have leveraged molecular information…