Joseph having a hard time in keeping his new hat in the head!
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Ph.D./Posdoc position in computational medical epigenomics
Fragment size of ATAC-seq reads indicate local chromatin architecture. The Institute for Computational Genomics, RWTH Aachen University performs cutting edge research on computational and genomic methods for understanding regulatory and epigenetic processes driving cell differentiation and diseases (Gusmao, Nature Methods,…
Ph.D./Posdoc position in computational detection of RNA-DNA triple helices
The Institute for Computational Genomics, RWTH Aachen University performs cutting edge research on computational and genomic methods for understanding regulatory and epigenetic processes driving cell differentiation and diseases (Gusmao, Nature Methods, 2016, Li, Genome Biology, 2019). This project aims studying…
Influence of western diet in immune cells with single cell sequencing
Collaborative work with Krenkel and Tacke dissect changes in immune cells of mice subjected to high fat / high sugar diets.
Footprinting in ATAC-seq published in Genome Biology
Our paper on HINT-ATAC is finally out in Genome Biology!
Decoding the function of lncRNAs – New computational metohd & sequencing protocols for detection of RNA-DNA Triple Helices
A paper describing TDF- a framework for detection of triple helix forming RNAs – is finally out in NAR! Moreover with Grummt Lab, we have performed computational analysis of TripleRNA-seq and TriplexDNA-seq; two novel protocols for returning DNA/RNA molecules forming…
Open positions
We perform research on computational methods for analysis of epigenomics and transcriptomics data. Over the past years, we have developed methods for prediction of cell specific binding sites from open chromatin data (Gusmao et al., Bioinformatics, 2015; Nature Methods, 2016),…
Decoding the function of lncRNAs – Paper in Cell Stem Cell
Together with Kurian lab, we have delineated bionformatics framework to uncover novel antisense lncRNAs during cardiomyocite differentiation. These were particularly positioned up-stream of transcription factors, and showed a high positive correlation with these anti-sense partners.In this paper, Frank and colleagues…
Papers in PNAS, Leukemia and Molecular Cell
A few successful collaborative efforts were recently published in top biomedical journals. With Zirkel and colleagues we used HINT footprint analysis to characterize transcription factor binding underlying DNA looping via HMGB2. With Sonntag and colleagues, we have leveraged molecular information…
Project funded by DFG – Bioinformatics of Open Chromatin
The DFG has approved a “sachbeihilfe” project for the research on computational methods for analysis of open chromatin from single cell sequencing.
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