Category: Uncategorized

Andre Camara defended his PhD

Andre Camara, who was jointly co-supervised by Prof. Ricardo Prudencio and our group, has successfully completed his Ph.D. degree at the Federal University of Pernambuco. His dissertation proposed a new methodology for prediction of drug-protein interactions by combining multiple information

Uncovering regulatory networks during dendritic cell differentiation in NAR

Together with the cell biology department, we have investigated changes in histone modifications and binding of the master regulator Pu.1 during dendritic cell differentiation. We have derived a computational approach to detect further co-binding partners of PU.1 uncovering an regulatory

New Member – Fabio Ticoni

Fabio Ticconi has just joined the group as a Ph.D. candidate. Welcome!

Talk at IFCS 2015 on Detection of DNA methylation signatures

Marcelo Freitas will give a talk on the International Federation of Classification Societies. He will discuss about this lattest work on prediction of signatures from highly dimensional DNA methylation data for prediction of patient age.    

Publication in Clinical Epigenetics – Senecense and Nuclear Organization

In Hanzellman et al., we show how senescence-associated DNA hypermethylation occurs at specific sites in the genome and reflects functional changes in the course of replicative senescence.

Talk in RegGen/ISMB 2015 – Detection of DNAse footprints

Eduardo Gusmao will give a talk on the latest developments of the DNase-Seq footprinting method HINT on the Regulatory Genomics Special Interest Group at ISMB.

PhD Position in Bioinformatics of lncRNAs and Epigenomics (closed)

The Computational Biology Group of Interdisciplinary Center for Clinical Research (IZKF) Aachen, RWTH Aachen University Hospital,  Aachen, invites applicants for a PhD candidate  position in bioinformatics in one of the following topics: 1) Statistical machine learning methods for the analysis of medical epigenomics

Release of Differential Peak Calling Tool ODIN

We have released the first version of the differential peak caller ODIN. Please check ODIN’s website and it’s publication for more information.

Method for Detection of DNAse footprints

We have published the first method successfully integrating histone modification and DNAse-seq profiles for identification of cell active binding sites in Bioinformatics jornal. You can find our tool to detect footprints here.

Paper Published in Nucleic Acids Research

On a collaboration with the Biochemistry Institute, UK Aachen, we have used NGS data from histone modifications and transcription factors to show the role of MYC in inducing histone modification supporting gene transcription. Check the manuscript here.