We invite applicants for a PhD position in computational methods to dissect DNA methylation changes and their impact in regulatory features of cells upon aging in humans. The candidate will develop bioinformatic methods for detection of age associated DNA methtylation …
Ph.D. position (m/f/d) in Epigenomics Bioinformatics Read more »
Our paper on HINT-ATAC is finally out in Genome Biology!
A paper describing TDF- a framework for detection of triple helix forming RNAs – is finally out in NAR! Moreover with Grummt Lab, we have performed computational analysis of TripleRNA-seq and TriplexDNA-seq; two novel protocols for returning DNA/RNA molecules forming …
We perform research on computational methods for analysis of epigenomics and transcriptomics data. Over the past years, we have developed methods for prediction of cell specific binding sites from open chromatin data (Gusmao et al., Bioinformatics, 2015; Nature Methods, 2016), …
Together with Kurian lab, we have delineated bionformatics framework to uncover novel antisense lncRNAs during cardiomyocite differentiation. These were particularly positioned up-stream of transcription factors, and showed a high positive correlation with these anti-sense partners.In this paper, Frank and colleagues …
Decoding the function of lncRNAs – Paper in Cell Stem Cell Read more »
A few successful collaborative efforts were recently published in top biomedical journals. With Zirkel and colleagues we used HINT footprint analysis to characterize transcription factor binding underlying DNA looping via HMGB2. With Sonntag and colleagues, we have leveraged molecular information …
The DFG has approved a “sachbeihilfe” project for the research on computational methods for analysis of open chromatin from single cell sequencing.
Our paper revisiting footprinting analysis from DNase-Seq with HINT-BC has been accepted in Nature Methods. Check the paper here.
In a joint effort with Marcel Schulz (MPI Saarbrucken) and Matthias Heinig (Helmholtz Center Munich) , we will offer a tutorial on bioinformatics methods for detection of regulatory networks from NGS data. The tutorial will take place this summer within the international bioinformatics …
Tutorial on Inference of Regulatory Networks at ISMB/ECCB 2017 Read more »
The Costa lab has participated in several collaborative works, which has been published in important journals in the recent months. In Axelsson et al., Nature Communications, we have contributed on inference of gene expression based networks from type 2 diabetes patients. This …
Collaborative work published in Nature Communications, Genome Research and Gut Read more »
