In a joint effort, the Institute for Computational Genomics at the Uniklinik RWTH Aachen and collaborators from Ulm University (Germany) and the Cochin Institute (Paris, France) have characterized the role of the transcription factor ONECUT1 in diabetes, which was recently …
Work on genetic variants in ONECUT1 associated to diabetes accepted in Nature Medicine Read more »
A tour the force led by @rschneiderlab on the characterization of rare stromal cells supporting myelofibrosis. From scRNA in mouse and human to markers for early disease detection and potential therapeutics just publised in Cell Stem Cell https://www.sciencedirect.com/science/article/pii/S1934590920305427
We are looking for an experienced bioinformatician for helping the creation a spatial map of fibrosis. The candidate will develop bioinformatic methods for tracking temporal changes of single cells and integrative analysis of scRNA-seq, scATAC-seq and spatial information. This position …
The Federal Ministry of Education and Research (BMBF) is funding the research project „Spatial Mapping of Single Cells in Fibrotic Disease“, FibroMap for short, of the Uniklinik RWTH Aachen with 3.3 million euros. The Aachen scientists Prof. Dr. med. Dr. …
Funding of the BMBF Consortia / Spatial Map of Fibrosis Read more »
Imputation and footprinting for single cell ATAC-seq. New manuscript & software release! scOpen deals with massive sparsity and dropout events of single cell ATAC-seq. Use of scOpen improves clustering, inference of regulators and chromatin conformation. scHINT dissect regulatory & temporal …
Imputation and footprinting for single cell ATAC-seq. New manuscript & software release! Read more »
Collaborative work with Krenkel and Tacke dissect changes in immune cells of mice subjected to high fat / high sugar diets.
We invite applicants for a PhD position in integrative analysis of single cell transcriptomics and open chromatin data to dissect fibrosis on kidney diseases. The candidate will develop bioinformatic methods for tracking temporal changes of single cells and methods to …
Ph.D. position (m/f/d) in Single Cell Bioinformatics Read more »
We invite applicants for a PhD position in computational methods to dissect DNA methylation changes and their impact in regulatory features of cells upon aging in humans. The candidate will develop bioinformatic methods for detection of age associated DNA methtylation …
Ph.D. position (m/f/d) in Epigenomics Bioinformatics Read more »
Our paper on HINT-ATAC is finally out in Genome Biology!
