In Kalwa et al, 2016, we have applied for the first time the “Triplex Domain Finder” (TDF) to analyse DNA regions potentially regulated by HOTAIR, i.e. peaks of ChIRP-Seq experiments or regions with DNA methylation changes after siHOTAIR. TDF not …
Computational prediction of HOTAIR binding to DNA Read more »
The paper describing our differential peak caller supporting replicates have been published in Nucleic Acids Research. Allhoff, M., Sere K., Freitas, J., Zenke, M., Costa, I.G. (2016), Differential Peak Calling of ChIP-seq Signals with Replicates with THOR, Nucleic Acids Research, …
Publication on differential peak caller THOR in NAR Read more »
Manuel Allhoff has successfully defended his Informatics Ph.D. Congrats Batmanu!
Lin Q., Weidner C. I., Costa I. G., Marioni, R., Ferreira M. R. P. , Deary I. J., Wagner W., DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy?, Aging, accepted.
Andre Camara, who was jointly co-supervised by Prof. Ricardo Prudencio and our group, has successfully completed his Ph.D. degree at the Federal University of Pernambuco. His dissertation proposed a new methodology for prediction of drug-protein interactions by combining multiple information …
Together with the cell biology department, we have investigated changes in histone modifications and binding of the master regulator Pu.1 during dendritic cell differentiation. We have derived a computational approach to detect further co-binding partners of PU.1 uncovering an regulatory …
Uncovering regulatory networks during dendritic cell differentiation in NAR Read more »
Fabio Ticconi has just joined the group as a Ph.D. candidate. Welcome!
Marcelo Freitas will give a talk on the International Federation of Classification Societies. He will discuss about this lattest work on prediction of signatures from highly dimensional DNA methylation data for prediction of patient age.
In Hanzellman et al., we show how senescence-associated DNA hypermethylation occurs at specific sites in the genome and reflects functional changes in the course of replicative senescence.
Eduardo Gusmao will give a talk on the latest developments of the DNase-Seq footprinting method HINT on the Regulatory Genomics Special Interest Group at ISMB.
